Description

1-Bromo-4-Methylisoquinoline is a high-value halogenated isoquinoline derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the versatile 4-methylisoquinoline scaffold with a reactive bromine handle for further functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for kinase inhibitors, anticancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the isoquinoline core for biological activity.
• Material Science: Serves as a monomer or functional unit in the creation of organic semiconductors, ligands for catalysts, and advanced polymers.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions to create diverse chemical libraries for screening.
• Ligand Preparation: Useful for synthesizing novel chelating ligands used in coordination chemistry and catalysis.

Basic Information

Item	Details
Product Name	1-Bromo-4-Methylisoquinoline
CAS No.	1542564-70-4
Molecular Formula	C10H8BrN
Molecular Weight	222.08 g/mol
Synonyms	4-Methyl-1-bromoisoquinoline; 1-Bromo-4-methylisoquinoline; 1-Bromo-4-methyl-isoquinoline; 4-Methylisoquinolin-1-yl bromide; 1-Bromo-4-methyl-2-azanaphthalene; 1542564-70-4; Bromo-methylisoquinoline
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Methylisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.