Description

15-Deoxy-δ12,14-Prostaglandin J2-D4 is a deuterated analog of the bioactive cyclopentenone prostaglandin, 15d-PGJ2, serving as a critical internal standard for precise quantitative analysis in mass spectrometry. This compound is essential for researchers requiring high-fidelity measurement of endogenous 15d-PGJ2 levels in complex biological matrices. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on inflammation, metabolism, and cell signaling pathways.

Application

• Mass Spectrometry Internal Standard: Used as a deuterium-labeled internal standard for the accurate quantification of endogenous 15d-PGJ2 via LC-MS/MS and GC-MS methods.
• Biomarker Research: Enables precise measurement of 15d-PGJ2 as a biomarker in studies of oxidative stress, inflammation, and PPARγ activation.
• Metabolic Pathway Analysis: Critical for tracing and quantifying arachidonic acid metabolism and prostaglandin synthesis in in vitro and in vivo models.
• Pharmaceutical Development: Supports drug discovery programs targeting the PPARγ pathway, inflammation, and metabolic disorders by providing reliable analytical reference data.
• Clinical Research: Facilitates the development of diagnostic assays for conditions where 15d-PGJ2 levels are clinically relevant.

Basic Information

Product Name	15-Deoxy-δ12,14-Prostaglandin J2-D4
CAS No.	1542166-82-4
Molecular Formula	C20H28D4O3
Molecular Weight	320.48 g/mol
Synonyms	15-Deoxy-δ12,14-PGJ2-D4; 15d-PGJ2-D4; 9,10-Didehydro-15-deoxy-δ12,14-prostaglandin J2-d4; 15-Deoxy-δ-12,14-prostaglandin J2-d4; Deuterated 15d-PGJ2; PGJ2-d4; 15-Deoxy-δ(12,14)-prostaglandin J2-13,14,20,20-d4
EINECS	Contact for details

Quality Control

Every batch of 15-Deoxy-δ12,14-Prostaglandin J2-D4 is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment, verified by advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.