Description

8-Fluoro-Isoquinoline-5-Carboxylic Acid Methyl Ester is a high-value fluorinated isoquinoline derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine and the versatile methyl ester functional group, enabling precise molecular modifications for developing novel compounds. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Fluorine Chemistry: A valuable scaffold for introducing fluorine atoms into complex molecules to modulate their bioavailability, metabolic stability, and binding affinity.
• Material Science: Potential building block for creating specialty polymers, liquid crystals, or organic electronic materials.
• Chemical Biology: Useful as a probe or tag in medicinal chemistry and biochemical research due to its fluorinated structure.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs for client-specific synthetic routes.

Basic Information

Product Name	8-Fluoro-Isoquinoline-5-Carboxylic Acid Methyl Ester
CAS No.	1540628-23-6
Molecular Formula	C11H8FNO2
Molecular Weight	205.19 g/mol
Synonyms	Methyl 8-fluoro-5-isoquinolinecarboxylate; 8-Fluoro-5-isoquinolinecarboxylic acid methyl ester; 8-Fluoro-5-methoxycarbonylisoquinoline; 5-(Methoxycarbonyl)-8-fluoroisoquinoline; 1540628-23-6; 8-Fluoro-isoquinoline-5-carboxylic acid methyl ester; 8-Fluoro-5-carbomethoxyisoquinoline
EINECS	Contact for details

Quality Control

Our 8-Fluoro-Isoquinoline-5-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure full traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.