Description

Carfilzomib-D8 is a deuterated analog of the proteasome inhibitor Carfilzomib, specifically designed for use as an internal standard in quantitative bioanalytical research. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical researchers and analytical laboratories developing and validating methods for the precise measurement of Carfilzomib in complex biological matrices.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Carfilzomib.
• Supporting pharmacokinetic (PK) and bioanalytical studies in drug development and clinical research.
• Enabling accurate metabolite profiling and identification studies for Carfilzomib.
• Critical component in method development and validation to meet regulatory standards (e.g., FDA, EMA).
• Use in doping control and forensic analysis where precise measurement of proteasome inhibitors is required.
• Application in academic research investigating the mechanisms of proteasome inhibition and related cellular pathways.

Basic Information

Product Name	Carfilzomib-D8
CAS No.	1537187-53-3
Molecular Formula	C40H49D8N5O7
Molecular Weight	720.96 g/mol (deuterated form)
Synonyms	Carfilzomib-d8; (2S)-N-((S)-1-((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-4-methylpentanamido)-4-methylpentanamide-d8; Kyprolis-d8; PR-171-d8; Proteasome Inhibitor Carfilzomib-d8; Deuterated Carfilzomib
EINECS	Contact for details

Quality Control

Our Carfilzomib-D8 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to cGMP principles for the production of reference standards, supporting regulatory submissions and high-stakes research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.