Description

5-Bromo-8-Fluoro-1,2-Dihydroisoquinolin-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated isoquinolinone structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in targeted protein degradation platforms.
• Kinase Inhibitor Synthesis: Employed in the construction of potential kinase inhibitors due to the privileged isoquinolinone structure.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Item	Detail
Product Name	5-Bromo-8-Fluoro-1,2-Dihydroisoquinolin-1-One
CAS No.	1536364-85-8
Molecular Formula	C9H5BrFNO
Molecular Weight	242.05 g/mol
Synonyms	5-Bromo-8-fluoro-1,2-dihydroisoquinolin-1-one; 5-Bromo-8-fluoro-1H-isoquinolin-1-one; 1536364-85-8; 8-Fluoro-5-bromo-1,2-dihydroisoquinolin-1-one; 5-Bromo-8-fluoro-1,2-dihydro-isoquinolin-1-one; 1H-Isoquinolin-1-one, 5-bromo-8-fluoro-1,2-dihydro-
EINECS	Contact for details

Quality Control

Our 5-Bromo-8-Fluoro-1,2-Dihydroisoquinolin-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and adherence to ICH guidelines ensure the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.