Description

(4R,6S)-Rel-5,6-Dihydro-4-Hydroxy-6-Methyl-4H-Thieno[2,3-B]Thiopyran-2-Sulfonamide 7,7-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure containing fused thiophene and thiopyran rings. This compound matters as a critical chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), where its stereochemistry and functional groups are essential for biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the research and synthesis of new drug candidates.
• API Development: Used in constructing the core structure of potential APIs targeting specific enzymes or receptors.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in academic and industrial R&D labs.
• Process Chemistry: Employed in route scouting and optimization for scalable manufacturing of complex molecules.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control.
• Custom Synthesis: Acts as a starting material for the preparation of more complex, proprietary derivatives.

Basic Information

Product Name	(4R,6S)-Rel-5,6-Dihydro-4-Hydroxy-6-Methyl-4H-Thieno[2,3-B]Thiopyran-2-Sulfonamide 7,7-Dioxide
CAS No.	1533443-76-3
Molecular Formula	C9H11NO5S3
Molecular Weight	317.38 g/mol
Synonyms	(4R,6S)-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; Rel-(4R,6S)-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; Thieno[2,3-b]thiopyran-2-sulfonamide derivative; CAS 1533443-76-3; Bicyclic sulfonamide intermediate; Chiral thiopyran sulfonamide.
EINECS	Contact for details

Quality Control

Our (4R,6S)-Rel-5,6-Dihydro-4-Hydroxy-6-Methyl-4H-Thiopyran-2-Sulfonamide 7,7-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure compliance with research and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity (HPLC), and specific tests are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.