Description

tert-Butyl 4-Hydroxypiperidine-1-Carboxylate-3,3,4,5,5-D5 is a high-purity, deuterium-labeled derivative of a key piperidine-based building block. This compound is specifically designed for advanced research and development, offering a stable isotopic label for precise metabolic, pharmacokinetic, and mechanistic studies. It is an essential intermediate for pharmaceutical chemists and researchers in the life sciences sector, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and for use as an internal standard in mass spectrometry.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of deuterated drug candidates and novel therapeutic agents.
• Metabolic Tracing: Used as a stable isotope-labeled tracer in drug metabolism and pharmacokinetics (DMPK) studies to track compound fate in biological systems.
• Internal Standard for LC-MS/MS: Provides high accuracy and precision in quantitative bioanalytical methods due to its isotopic purity, minimizing matrix effects.
• Mechanistic Research: Enables investigation of reaction pathways and enzymatic processes in medicinal chemistry and biochemistry.
• API Development: Serves as a precursor in the development of deuterium-switched pharmaceuticals, which can offer improved metabolic profiles.
• Chemical Biology Probes: Utilized in the creation of labeled probes for target engagement and binding studies.

Basic Information

Product Name	tert-Butyl 4-Hydroxypiperidine-1-Carboxylate-3,3,4,5,5-D5
CAS No.	1523606-18-9
Molecular Formula	C10H14D5NO3
Molecular Weight	204.29 g/mol (for deuterated form)
Synonyms	1-Boc-4-hydroxypiperidine-d5; 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-3,3,4,5,5-d5; 4-Hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester-d5; N-Boc-4-hydroxypiperidine-d5; tert-Butyl 4-hydroxy-1-piperidinecarboxylate-d5; 4-Hydroxy-N-Boc-piperidine-d5; Boc-4-hydroxypiperidine-d5; 1-Boc-4-piperidinol-d5
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced under stringent quality control protocols to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) are provided, detailing assay, isotopic enrichment, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.