Description

tert-Butyl 5-(3-Methoxy-2,2-Dimethyl-3-Oxopropyl)Thiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific thiophene-carboxylate ester structure. This compound is of critical importance for enabling complex synthetic routes in modern drug discovery and development, particularly for active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly those containing functionalized thiophene cores.
• API Synthesis: Used in the research and development of Active Pharmaceutical Ingredients (APIs) for potential treatments in oncology, central nervous system (CNS) disorders, and anti-inflammatory applications.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for specialized client projects.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	tert-Butyl 5-(3-Methoxy-2,2-Dimethyl-3-Oxopropyl)Thiophene-2-Carboxylate
CAS No.	1512637-49-8
Molecular Formula	C15H22O4S
Molecular Weight	298.40 g/mol
Synonyms	tert-Butyl 5-(3-methoxy-2,2-dimethyl-3-oxopropyl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-[3-methoxy-2,2-dimethyl-3-oxopropyl]-, 1,1-dimethylethyl ester; 5-(3-Methoxy-2,2-dimethyl-3-oxopropyl)thiophene-2-carboxylic acid tert-butyl ester; tert-Butyl 5-(3-methoxy-2,2-dimethyl-3-oxopropyl)-2-thiophenecarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(3-Methoxy-2,2-Dimethyl-3-Oxopropyl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.