Description

4-Fluoro-6-Nitroisoquinolin-1(2H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused-ring structure containing both fluorine and nitro substituents. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting specific enzyme inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic molecules.
• Organic Synthesis Building Block: Serves as a versatile scaffold for constructing more complex nitrogen-containing heterocycles due to its reactive nitro and carbonyl groups.
• Agrochemical Research: Potential intermediate in the development of new herbicides or pesticides, leveraging its fluorinated isoquinoline core.
• Material Science Exploration: Investigated as a potential component in the synthesis of organic electronic materials or specialty dyes.

Basic Information

Product Name	4-Fluoro-6-Nitroisoquinolin-1(2H)-One
CAS No.	1508295-22-4
Molecular Formula	C9H5FN2O3
Molecular Weight	208.15 g/mol
Synonyms	1(2H)-Isoquinolinone, 4-fluoro-6-nitro-; 4-Fluoro-6-nitro-1(2H)-isoquinolinone; 4-Fluoro-6-nitro-1,2-dihydroisoquinolin-1-one; 6-Nitro-4-fluoro-1,2-dihydroisoquinolin-1-one; 4-Fluoro-6-nitroisoquinolin-1-ol (tautomer); 4-Fluoro-6-nitro-2H-isoquinolin-1-one; 1508295-22-4
EINECS	Contact for details

Quality Control

Our 4-Fluoro-6-Nitroisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.