Description

5-Bromo-1-Chloro-8-Fluoroisoquinoline CAS NO 1501083-37-9 is a high-purity, multi-halogenated isoquinoline derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a valuable scaffold for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and material science applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and halogen atoms for bioactivity.
• Material Science: Serves as a monomer or functional unit in the creation of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology: Employed as a molecular probe or tag due to its distinct halogen atoms, useful in bioconjugation and labeling studies.
• Catalyst Ligand Synthesis: Acts as a starting material for constructing sophisticated nitrogen-containing ligands used in transition metal catalysis.
• Academic & Contract Research: Essential for methodological development and exploring new reaction pathways in heterocyclic and medicinal chemistry.

Basic Information

Product Name	5-Bromo-1-Chloro-8-Fluoroisoquinoline
CAS No.	1501083-37-9
Molecular Formula	C9H4BrClFN
Molecular Weight	260.49 g/mol
Synonyms	1-Chloro-5-bromo-8-fluoroisoquinoline; 8-Fluoro-5-bromo-1-chloroisoquinoline; 5-Bromo-1-chloro-8-fluoro-isoquinoline; Isoquinoline, 5-bromo-1-chloro-8-fluoro-; 1501083-37-9; 5-Br-1-Cl-8-F-isoquinoline
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Chloro-8-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.