Description

3-(Trifluoromethyl)-1,4,5,6-Tetrahydrocyclopenta[C]Pyrazole-5-Carboxylic Acid (Wx112242) is a high-purity, advanced pharmaceutical intermediate featuring a unique fused cyclopentapyrazole scaffold substituted with a trifluoromethyl group. This compound is of significant commercial interest due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting inflammation and metabolic disorders. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating new molecular entities with enhanced potency and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the synthesis of new-generation herbicides and pesticides, leveraging the biological activity of the pyrazole core.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands and functional molecules used in catalysis and polymer science.
• Chemical Biology Probe: Employed in medicinal chemistry to study structure-activity relationships (SAR) and optimize lead compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production of client-specific molecules.

Basic Information

Product Name	3-(Trifluoromethyl)-1,4,5,6-Tetrahydrocyclopenta[C]Pyrazole-5-Carboxylic Acid (Wx112242)
CAS No.	1495681-98-5
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-cyclopenta[c]pyrazole-5-carboxylic acid; 3-(Trifluoromethyl)-1,4,5,6-tetrahydrocyclopentapyrazole-5-carboxylic acid; 5-Carboxy-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-cyclopenta[c]pyrazole; WX-112242; WX112242; CAS 1495681-98-5; 1,4,5,6-Tetrahydro-3-(trifluoromethyl)cyclopenta[c]pyrazole-5-carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethyl)-1,4,5,6-Tetrahydrocyclopenta[C]Pyrazole-5-Carboxylic Acid is manufactured under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.