Description

1H-Isoindole, 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, protected boronic ester derivative of isoindoline, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors, where it is used to build advanced molecular architectures for active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in constructing complex heterocyclic cores prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides by facilitating the introduction of the isoindoline moiety.
• Materials Science & OLED Development: Serves as a precursor for creating organic semiconductors, light-emitting materials, and other functional organic electronic components.
• Ligand & Catalyst Development: Employed in the synthesis of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology & Probe Synthesis: Utilized to create tagged molecules and bioconjugates for studying biological processes and diagnostic applications.
• Polymer & Resin Modification: Acts as a monomer or cross-linking agent for producing specialty polymers with tailored properties.

Basic Information

Product Name	1H-Isoindole, 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1491162-09-4
Molecular Formula	C14H18BNO2
Molecular Weight	243.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindole; 2,3-Dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-isoindole; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline; Isoindoline-5-boronic acid pinacol ester; 5-Pinacolatoborylisoindoline; 5-Boronoisoindoline pinacol ester; 1H-Isoindole-5-boronic acid, 2,3-dihydro-, 1,1,2,2-tetramethylethylene ester
EINECS	Contact for details

Quality Control

Every batch of our 1H-Isoindole, 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, critical for sensitive cross-coupling reactions. Our standard quality protocol includes HPLC, NMR, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, we recommend storage at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.