Description

Nicotelline-D8 is a stable isotope-labeled analog of nicotelline, where eight hydrogen atoms are replaced by deuterium, making it an essential internal standard for precise analytical quantification. This high-purity compound is critical for ensuring accuracy and reliability in mass spectrometry-based methods, eliminating variability and improving data integrity. It is primarily utilized by analytical laboratories and research institutions in the fields of tobacco alkaloid research, forensic toxicology, and environmental analysis.

Application

• Internal Standard for LC-MS/MS and GC-MS: Used for the accurate quantification of nicotelline and related alkaloids in complex matrices.
• Tobacco and Smoke Research: Enables precise measurement of tobacco-specific nitrosamine (TSNA) precursors and alkaloid biomarkers in smoke condensate and biological samples.
• Forensic and Clinical Toxicology: Supports method development and validation for detecting tobacco exposure and related compounds in human fluids and tissues.
• Environmental Monitoring: Aids in tracing and quantifying tobacco-derived pollutants and alkaloid residues in environmental samples.
• Metabolomic Studies: Serves as a stable isotope tracer in research investigating the metabolic pathways and fate of nicotine and its derivatives.
• Pharmaceutical Reference Standard: Used in quality control and method development for products related to nicotine replacement therapy or smoking cessation.

Basic Information

Product Name	Nicotelline-D8
CAS No.	1469367-99-4
Molecular Formula	C10H4D8N2
Molecular Weight	168.24 g/mol
Synonyms	Nicotelline-d8; [2,3',4',5,5',6,6'-D8]-3-(3-Pyridinyl)pyridine; Deuterated Nicotelline; 3,3'-Bipyridine-d8; Nicotelline (D8); 3-(Pyridin-3-yl)pyridine-d8; Perdeuterated Nicotelline; Isotopic Internal Standard Nicotelline
EINECS	Contact for details

Quality Control

Every batch of Nicotelline-D8 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocols are designed to meet the stringent requirements of analytical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.