Description

tert-Butyl3-Amino-4-(Hydroxymethyl)-3-(Isothiazol-5-Yl)Pyrrolidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex pyrrolidine scaffold functionalized with amino, hydroxymethyl, and isothiazolyl groups. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as neurology and infectious diseases, where its unique heterocyclic structure enables the exploration of new drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex, biologically active molecules and potential new chemical entities (NCEs).
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• API Development: Serves as a precursor in the multi-step synthesis of candidate drugs, particularly those targeting central nervous system (CNS) disorders.
• Process Chemistry & Scale-Up: Employed in route scouting and process development for the efficient, scalable production of target molecules.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs engaged in custom synthesis and development services for pharmaceutical clients.
• Academic Research: Used in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl3-Amino-4-(Hydroxymethyl)-3-(Isothiazol-5-Yl)Pyrrolidine-1-Carboxylate
CAS No.	1463484-93-6
Molecular Formula	C13H21N3O3S
Molecular Weight	299.39 g/mol
Synonyms	1-Boc-3-amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine; tert-Butyl 3-amino-4-(hydroxymethyl)-3-(1,2-thiazol-5-yl)pyrrolidine-1-carboxylate; 5-Pyrrolidinecarboxylic acid, 3-amino-4-(hydroxymethyl)-3-(5-isothiazolyl)-, 1,1-dimethylethyl ester; 3-Amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-3-Amino-4-(hydroxymethyl)-3-(isothiazol-5-yl)pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl3-Amino-4-(Hydroxymethyl)-3-(Isothiazol-5-Yl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.