Description

Boronic Acid, B-(2,4-Dichloro-5-Pyrimidinyl)- is a high-purity, halogenated pyrimidine boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecules in pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists working in pharmaceutical intermediates, agrochemicals, and advanced material science.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core for biological activity.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Biology & Medicinal Chemistry: Acts as a versatile handle for bioconjugation and the development of enzyme inhibitors or molecular probes.
• Process Chemistry & Scale-up: Suitable for optimization and scale-up from laboratory to pilot plant scale for commercial production.

Basic Information

Product Name	Boronic Acid, B-(2,4-Dichloro-5-Pyrimidinyl)-
CAS No.	1457945-86-6
Molecular Formula	C4H3BCl2N2O2
Molecular Weight	216.80 g/mol
Synonyms	(2,4-Dichloropyrimidin-5-yl)boronic acid; 5-Borono-2,4-dichloropyrimidine; 2,4-Dichloro-5-pyrimidineboronic acid; B-(2,4-Dichloro-5-pyrimidinyl)boronic acid; 2,4-Dichloro-5-pyrimidinylboronic acid; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dichloropyrimidine (Pinacol ester precursor)
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-(2,4-Dichloro-5-Pyrimidinyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.