Description

Methyl 1-Bromo-4-Hydroxy-7-Phenoxyisoquinoline-3-Carboxylate is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and the synthesis of proprietary compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel isoquinoline-based drug candidates, particularly for therapeutic areas requiring complex heterocyclic cores.
• Agrochemical Research: Serves as a building block for developing new pesticides and herbicides, leveraging the biological activity of the brominated isoquinoline structure.
• Material Science: Used in the research and development of organic electronic materials, such as OLEDs or charge-transport materials, due to its conjugated phenoxy-isoquinoline system.
• Chemical Biology Probe Development: Employed as a scaffold for creating fluorescent tags or molecular probes to study biological processes.
• Academic & Contract Research: Essential for methodological studies in organic chemistry, including cross-coupling reactions and heterocycle functionalization.
• Custom Synthesis & Scale-Up: A critical starting material for contract manufacturing organizations (CMOs) producing custom, high-value compounds for client projects.

Basic Information

Product Name	Methyl 1-Bromo-4-Hydroxy-7-Phenoxyisoquinoline-3-Carboxylate
CAS No.	1455091-21-0
Molecular Formula	C17H12BrNO4
Molecular Weight	374.19 g/mol
Synonyms	1-Bromo-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester; Methyl 1-bromo-4-hydroxy-7-phenoxy-3-isoquinolinecarboxylate; 3-Isoquinolinecarboxylic acid, 1-bromo-4-hydroxy-7-phenoxy-, methyl ester; 1-Bromo-4-hydroxy-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester; 1455091-21-0; Methyl 1-bromo-4-hydroxy-7-phenoxy-3-quinolinecarboxylate (common misnomer)
EINECS	Contact for details

Quality Control

Our Methyl 1-Bromo-4-Hydroxy-7-Phenoxyisoquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GLP and cGMP environments, ensuring reliable performance in your most sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.