Description

3-[(tert-Butyldiphenylsilyl)Oxy]-3-Methylazetidine is a high-value, protected azetidine derivative, a crucial building block in modern organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex nitrogen-containing heterocycles, which are core scaffolds in numerous active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries, enabling the synthesis of novel compounds with potential therapeutic and biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel azetidine-based drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce and protect the azetidine moiety during multi-step synthetic routes.
• Process Chemistry & Scale-up: Serves as a reliable starting material for the kilogram-scale production of advanced intermediates under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides that utilize nitrogen heterocycles for enhanced efficacy.
• Ligand & Catalyst Development: The tert-butyldiphenylsilyl (TBDPS) protected hydroxyl group allows for selective deprotection, making it useful in designing chiral ligands and organocatalysts.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and chemical biology probes.

Basic Information

Product Name	3-[(tert-Butyldiphenylsilyl)Oxy]-3-Methylazetidine
CAS No.	1455010-26-0
Molecular Formula	C20H27NOSi
Molecular Weight	325.52 g/mol
Synonyms	3-Methyl-3-[(tert-butyldiphenylsilyl)oxy]azetidine; 3-(tert-Butyldiphenylsilyloxy)-3-methylazetidine; 3-Methylazetidin-3-ol, tert-butyldiphenylsilyl ether; TBDPS-protected 3-Methyl-3-hydroxyazetidine; 3-(TBDPS-Oxy)-3-methylazetidine; 3-(tert-Butyldiphenylsiloxy)-3-methylazetidine; Azetidine, 3-[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-
EINECS	Contact for details

Quality Control

Our 3-[(tert-Butyldiphenylsilyl)Oxy]-3-Methylazetidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.