Description

1,2-Ethanediol, 1-(4-Chloro-3-Fluorophenyl)-, (1R)- is a high-purity chiral intermediate of significant importance in modern synthetic chemistry. This compound is valued for its role as a key building block in the synthesis of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily needed by research institutions and manufacturers developing advanced active pharmaceutical ingredients (APIs) and fine chemicals, where stereochemical purity is critical for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially in therapeutic areas requiring high stereoselectivity.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the specific stereochemistry can influence biological activity and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a specialized intermediate in the synthesis of fluorinated organic compounds for electronic display technologies.
• Asymmetric Catalysis Research: Employed as a ligand precursor or a model substrate in the development of new chiral catalysts and synthetic methodologies.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for producing high-value, complex organic molecules.

Basic Information

Product Name	1,2-Ethanediol, 1-(4-Chloro-3-Fluorophenyl)-, (1R)-
CAS No.	1453854-84-6
Molecular Formula	C8H8ClFO2
Molecular Weight	190.60 g/mol
Synonyms	(1R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol; (R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol; (R)-1-(4-Chloro-3-fluorophenyl)ethylene glycol; 1,2-Ethanediol, 1-(4-chloro-3-fluorophenyl)-, (1R)-; (R)-4-Chloro-3-fluoromandelic alcohol; (R)-2-Hydroxy-2-(4-chloro-3-fluorophenyl)ethanol; Chiral fluorophenyl glycol derivative; (R)-CFP-Glycol
EINECS	Contact for details

Quality Control

Our production of 1,2-Ethanediol, 1-(4-Chloro-3-Fluorophenyl)-, (1R)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chiral purity. All materials are subjected to rigorous analytical testing, including chiral HPLC and NMR, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting compliance in cGMP-aligned applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.