Description

6-Bromo-2-Methylpyridine-3-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules in modern organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to introduce functionalized pyridine scaffolds into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyridine moieties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the pyridine ring is a core structural element.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and other functional organic compounds.
• Cross-Coupling Reactions: Specifically designed as a boronic ester reagent for efficient, palladium-catalyzed Suzuki-Miyaura couplings with various aryl/heteroaryl halides.
• Chemical Library Development: Employed in parallel and combinatorial synthesis to generate diverse compound libraries for high-throughput screening in drug discovery.
• Ligand and Catalyst Preparation: Useful for synthesizing novel bidentate or polydentate ligands containing pyridine and boronate ester functionalities.

Basic Information

Product Name	6-Bromo-2-Methylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	1451391-32-4
Molecular Formula	C₁₂H₁₇BBrNO₂
Molecular Weight	298.99 g/mol
Synonyms	2-Methyl-6-bromopyridine-3-boronic acid pinacol ester; (6-Bromo-2-methylpyridin-3-yl)boronic acid pinacol ester; 3-Bromo-6-methylpyridine-2-boronic acid pinacol ester; 6-Bromo-2-picoline-3-boronic acid pinacol ester; Pinacol (6-bromo-2-methylpyridin-3-yl)boronate; 1451391-32-4; Boronic acid, B-(6-bromo-2-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Methylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (¹H, ¹³C, ¹¹B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.