Description

2,3,4-Trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a high-purity, multifunctional boronic ester derivative of a fluorinated aniline, serving as a critical building block in modern synthetic chemistry. Its value lies in the combination of a reactive amine group and a protected boronic acid moiety, enabling sequential and selective cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex, fluorinated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used to construct fluorinated aromatic rings in advanced herbicides, fungicides, and insecticides, where fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), where its structure aids in tuning electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized bidentate ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized to synthesize fluorinated probes and tags for studying biological processes and protein interactions via positron emission tomography (PET) tracer development.
• Custom Synthesis & Contract Manufacturing: A vital raw material for custom synthesis organizations (CSOs) producing bespoke compounds for client R&D pipelines.

Basic Information

Item	Detail
Product Name	2,3,4-Trifluoro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1451391-20-0
Molecular Formula	C12H16BF3NO2
Molecular Weight	265.07 g/mol
Synonyms	2,3,4-Trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 2-Amino-3,4,5-trifluorophenylboronic acid pinacol ester; 3,4,5-Trifluoro-2-aminophenylboronic acid pinacol ester; 2,3,4-Trifluoro-6-(pinacolatoboryl)aniline; (2-Amino-3,4,5-trifluorophenyl)boronic acid pinacol ester; 1451391-20-0; Aniline, 2,3,4-trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Every batch of 2,3,4-Trifluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with custom purities up to 99%+ available. Comprehensive Certificates of Analysis (COA) detailing all test results are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.