Description

α-Linolenoyl Ethanolamide-D4 is a deuterated analog of the endogenous fatty acid ethanolamide, specifically the α-linolenic acid (ALA) conjugate. This stable isotope-labeled compound is a critical tool for quantitative bioanalytical research, enabling precise measurement and tracing of its endogenous counterpart in complex biological matrices. It is primarily utilized by researchers and analytical laboratories in the fields of lipidomics, endocannabinoid system studies, and metabolic pathway analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative internal standard for the accurate measurement of endogenous α-linolenoyl ethanolamide in biological samples like plasma, serum, and tissue homogenates.
• Metabolic Tracing Studies: Used in pharmacokinetic and metabolic flux studies to track the absorption, distribution, metabolism, and excretion (ADME) of related fatty acid ethanolamides.
• Biomarker Research: Facilitates the development and validation of high-sensitivity assays for potential lipid-based biomarkers in disease states.
• Endocannabinoid System Analysis: A key reagent for investigating the biosynthesis, degradation, and biological roles of N-acylethanolamines within the expanded endocannabinoid system.
• Method Development & Validation: Essential for developing robust, GLP-compliant analytical methods in pharmaceutical and academic research settings.
• Quality Control Reference Material: Used as a certified reference material (CRM) for calibrating instruments and ensuring data integrity in analytical testing laboratories.

Basic Information

Product Name	α-Linolenoyl Ethanolamide-D4
CAS No.	1451194-68-5
Molecular Formula	C20H29D4NO3
Molecular Weight	335.50 g/mol (for D4 isotopologue)
Synonyms	N-(α-Linolenoyl) Ethanolamide-D4; ALA-EA-D4; N-Docosa-9Z,12Z,15Z-trienoylethanolamide-D4; Linolenoylethanolamide-D4; 9Z,12Z,15Z-Octadecatrienoylethanolamide-D4; N-(9Z,12Z,15Z-Octadecatrienoyl)ethanolamine-D4; Deuterated ALEA; Arachidonoyl Ethanolamide Analog-D4 (structural analog)
EINECS	Contact for details

Quality Control

Our α-Linolenoyl Ethanolamide-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic purity (D4 content), and solvent residues are provided to ensure traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D4)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.