Description

3-(4-Chloro-1-Hydroxybutyl)-1H-Indole-5-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its specific indole-based molecular structure. This compound is of significant value in the synthesis of complex active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers seeking reliable, high-quality building blocks for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of proprietary drug candidates and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic agents.
• CNS Drug Synthesis: Serves as a precursor in the development of compounds targeting neurological and psychiatric disorders.
• Oncology Research: Employed in the synthesis of potential anti-cancer agents due to the indole scaffold's biological relevance.
• Contract Manufacturing: Supplied to CMOs and CDMOs for use in custom synthesis and scale-up projects under cGMP conditions.
• Fine Chemical Production: Integrated into the production of specialized, high-value fine chemicals and other advanced intermediates.

Basic Information

Product Name	3-(4-Chloro-1-Hydroxybutyl)-1H-Indole-5-Carbonitrile
CAS No.	1451194-34-5
Molecular Formula	C13H13ClN2O
Molecular Weight	248.71 g/mol
Synonyms	3-(4-Chloro-1-hydroxybutyl)-1H-indole-5-carbonitrile; 1H-Indole-5-carbonitrile, 3-(4-chloro-1-hydroxybutyl)-; 3-(4-Chloro-1-hydroxybutyl)indole-5-carbonitrile; 5-Cyano-3-(4-chloro-1-hydroxybutyl)indole; CAS 1451194-34-5
EINECS	Contact for details

Quality Control

Our 3-(4-Chloro-1-Hydroxybutyl)-1H-Indole-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to relevant standards for advanced pharmaceutical intermediates, supporting our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.