Description

2,2-Difluoro-2-Triphenylphosphaniumylacetate is a specialized organophosphorus reagent featuring a difluoroacetate moiety. This compound is valued for its role as a key intermediate in the synthesis of complex fluorinated molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of novel fluorinated pesticides and herbicides, leveraging fluorine's ability to enhance biological activity and stability.
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, or specialty materials with unique surface properties.
• Organic Synthesis Reagent: Acts as a difluorocarbene or difluoroacetate transfer agent in various name reactions for introducing CF2 groups.
• Catalyst Ligand Precursor: Potential use in modifying phosphine ligands for transition metal catalysis in asymmetric synthesis.
• Fluorine Chemistry Studies: Essential reagent for academic and industrial research focused on new methodologies in organofluorine chemistry.

Basic Information

Product Name	2,2-Difluoro-2-Triphenylphosphaniumylacetate
CAS No.	1449521-05-4
Molecular Formula	C20H15F2O2P
Molecular Weight	356.31 g/mol
Synonyms	Triphenylphosphonium 2,2-difluoroacetate; Difluoro(triphenylphosphoranylidene)acetate; 2,2-Difluoro-2-(triphenylphosphonio)acetate; 2,2-Difluoro-2-(triphenyl-λ5-phosphanylidene)acetate; (Carboxydifluoromethyl)triphenylphosphonium inner salt; Difluoro(oxo)acetate triphenylphosphonium ylide; DTPA (abbreviation).
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-Triphenylphosphaniumylacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 31P) and HPLC analysis, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.