Description

Benzo[B]Thiophene, 2,3-Dihydro-5-Iodo- is a high-purity iodinated heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and materials science. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise functionalization.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the thiophene core for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of organic electronic materials, such as organic semiconductors and OLED components.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a radiolabeling precursor when using iodine-125 or iodine-131.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form carbon-carbon bonds.
• Ligand Synthesis: Intermediate for the preparation of specialized ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Benzo[B]Thiophene, 2,3-Dihydro-5-Iodo-
CAS No.	1449384-45-5
Molecular Formula	C8H7IS
Molecular Weight	262.11 g/mol
Synonyms	5-Iodo-2,3-dihydro-1-benzothiophene; 5-Iodo-2,3-dihydrobenzo[b]thiophene; 2,3-Dihydro-5-iodobenzo[b]thiophene; 5-Iodo-2,3-dihydrobenzothiophene; Benzo[b]thiophene, 2,3-dihydro-5-iodo-; 1449384-45-5; AI3-31361
EINECS	Contact for details

Quality Control

Our Benzo[B]Thiophene, 2,3-Dihydro-5-Iodo- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.