Description

5-Trifluoromethyl-Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity fluorinated thiophene derivative, a crucial building block in advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the trifluoromethyl and ester functional groups on the thiophene scaffold. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Used in the synthesis of advanced organic electronic materials, such as organic semiconductors and conductive polymers, due to the electron-withdrawing nature of the substituents.
• Ligand and Catalyst Development: Employed in creating specialized ligands for transition metal catalysis and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Building Block: A versatile starting material for introducing the trifluoromethyl-thiophene moiety into more complex molecular architectures.
• Custom Synthesis and R&D: Supplied to contract research organizations (CROs) and academic institutions for discovery chemistry and process development.

Basic Information

Product Name	5-Trifluoromethyl-Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	1447913-55-4
Molecular Formula	C7H5F3O2S
Molecular Weight	210.17 g/mol
Synonyms	Methyl 5-(Trifluoromethyl)thiophene-3-carboxylate; 3-Thiophenecarboxylic acid, 5-(trifluoromethyl)-, methyl ester; Methyl 5-Trifluoromethyl-3-thiophenecarboxylate; 5-(Trifluoromethyl)thiophene-3-carboxylic acid methyl ester; 5-Trifluoromethyl-3-thiophenecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of 5-Trifluoromethyl-Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.