Description

Thiol-Peg3-T-Butyl Ester CAS NO 1446282-39-8 is a heterobifunctional polyethylene glycol (PEG) linker featuring a thiol group at one terminus and a tert-butyl ester-protected carboxylic acid at the other. This compound matters as a critical building block for creating stable, water-soluble conjugates in bioconjugation and drug delivery applications. Pharmaceutical researchers and biotech companies need it for the site-specific modification of peptides, proteins, and nanoparticles, enabling the development of advanced therapeutics and diagnostic agents.

Application

• Bioconjugation Reagent: For the site-specific coupling of thiol-containing biomolecules (e.g., cysteine residues in proteins/peptides) to carboxylic acid-functionalized surfaces or molecules.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a cleavable or non-cleavable spacer in the synthesis of antibody-drug conjugates, connecting cytotoxic payloads to targeting antibodies.
• PEGylation Agent: Used to introduce a hydrophilic PEG spacer onto drug molecules or nanoparticles to improve solubility, prolong circulation time, and reduce immunogenicity.
• Crosslinking and Surface Modification: Facilitates the functionalization of gold nanoparticles, quantum dots, or other materials via the thiol group for biosensing and imaging applications.
• Protease-Sensitive Prodrug Synthesis: The tert-butyl ester can be deprotected to yield a free carboxylic acid, which can be further activated for amide bond formation with amine-containing drug molecules.
• Polymer Chemistry: Acts as a chain transfer agent or functional initiator in the synthesis of tailored polymers with specific end-group functionality.

Basic Information

Product Name	Thiol-Peg3-T-Butyl Ester
CAS No.	1446282-39-8
Molecular Formula	C15H30O6S
Molecular Weight	338.46 g/mol
Synonyms	1,8-Dimercapto-3,6-dioxaoctane-8-carboxylic acid tert-butyl ester; 2,2-Dimethyl-4-oxo-3,8,11,14-tetraoxa-5-thiaheptadecan-17-oic acid tert-butyl ester; 17-(tert-Butoxy)-17-oxo-3,6,9,12-tetraoxa-16-thiaoctadecanoic acid; 3,6,9-Trioxa-12-thiatetradecan-1-oic acid, 14-(1,1-dimethylethyl) ester; SH-PEG3-COOtBu; HS-PEG3-t-butyl ester; tert-Butyl 3,6,9-trioxa-12-thiatetradecan-1-oate
EINECS	Contact for details

Quality Control

Our Thiol-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure compliance with high-purity research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or CoA. This product is easily oxidized and moisture-sensitive; allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.