Description

Bromo-Peg5-Phosphonic Acid CAS NO 1446282-37-6 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a bromoalkyl group and a phosphonic acid moiety. This compound is a critical building block in bioconjugation and materials science, enabling the precise functionalization of surfaces and biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing targeted drug delivery systems, diagnostic agents, and functionalized nanomaterials.

Application

• Bioconjugation Reagent: Used to attach phosphonate groups to peptides, proteins, or oligonucleotides via the bromo terminus for creating targeted therapeutics or diagnostic probes.
• Surface Functionalization: Key for modifying metal oxide surfaces (e.g., titanium, stainless steel) with a stable phosphonate anchor, followed by PEGylation to create non-fouling, biocompatible coatings for medical implants.
• Linker for Drug Delivery Systems: Serves as a versatile spacer in antibody-drug conjugates (ADCs) or nanoparticle formulations, connecting payloads to targeting ligands while improving solubility and pharmacokinetics.
• Materials Science Precursor: Employed in the synthesis of functional polymers and hydrogels where the phosphonic acid group provides chelating properties or adhesion to inorganic materials.
• Immobilization of Biomolecules: Facilitates the stable attachment of enzymes or catalysts on solid supports for bioprocessing and biosensor applications.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new bioconjugation strategies and advanced material interfaces.

Basic Information

Product Name	Bromo-Peg5-Phosphonic Acid
CAS No.	1446282-37-6
Molecular Formula	C15H32BrO9P
Molecular Weight	467.29 g/mol
Synonyms	5-Bromo-3,6,9,12,15-pentaoxa-2-azahaptadecan-17-ylphosphonic Acid; 2-[2-[2-[2-[2-Bromoethoxy]ethoxy]ethoxy]ethoxy]ethylamino]ethylphosphonic Acid; Br-PEG5-phosphonic Acid; Bromo-PEG5-Phosphonate; α-Bromo-ω-phosphonato-pentaethylene glycol; Bromo-Pentaethylene Glycol-Phosphonic Acid; N-(2-Bromoethoxyethyl)-O-[2-(phosphonooxy)ethyl]-diethylene glycol; Bromo-PEG5-Phosphonic Acid
EINECS	Contact for details

Quality Control

Our Bromo-Peg5-Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.