Description

1-(Bromomethyl)-2,4-Difluoro-3-(Trifluoromethyl)Benzene, 3-(Bromomethyl)-2,6-Difluorobenzotrifluoride is a high-value, multi-functional aromatic building block characterized by its bromomethyl and multiple fluorine substituents. This compound is essential for introducing the difluorobenzotrifluoride moiety into complex molecular architectures, enabling precise tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, particularly in the development of active pharmaceutical ingredients (APIs) with enhanced bioavailability and receptor binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores in electronic materials, contributing to the thermal stability and electro-optical performance of displays.
• Polymer Modification: Employed to introduce fluorinated benzyl groups into polymer chains, enhancing material properties such as chemical resistance, weatherability, and surface energy.
• Cross-Coupling Reactions: The bromomethyl group is a reactive handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• Organic Synthesis Building Block: A versatile reagent for nucleophilic substitution reactions, enabling the introduction of various functional groups via the reactive benzyl bromide site.

Basic Information

Item	Details
Product Name	1-(Bromomethyl)-2,4-Difluoro-3-(Trifluoromethyl)Benzene, 3-(Bromomethyl)-2,6-Difluorobenzotrifluoride
CAS No.	1445995-80-1
Molecular Formula	C9H4BrF5
Molecular Weight	287.03 g/mol
Synonyms	2,6-Difluoro-3-(bromomethyl)benzotrifluoride; 1-(Bromomethyl)-2,4-difluoro-3-(trifluoromethyl)benzene; 3-(Bromomethyl)-2,6-difluorobenzotrifluoride; α-Bromo-2,6-difluoro-3-(trifluoromethyl)toluene; 2,6-Difluoro-α-bromo-α,α,α-trifluoro-m-xylene; (2,6-Difluoro-3-(trifluoromethyl)phenyl)methyl bromide
EINECS	Contact for details

Quality Control

Every batch of 1-(Bromomethyl)-2,4-Difluoro-3-(Trifluoromethyl)Benzene is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.