Description

cis-2-(tert-Butoxycarbonyl)Octahydrocyclopenta[C]Pyrrole-3A-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex, conformationally constrained bicyclic structure. This compound is critical for medicinal chemistry research and development, serving as a key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers focused on developing therapeutics in areas such as central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Peptidomimetic Development: The constrained cyclopentapyrrolidine core serves as a proline or other amino acid mimic in the design of novel peptidomimetics and macrocyclic compounds.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic processes to introduce stereochemical complexity.
• API Process Development: Used during the scale-up and optimization phases for the commercial manufacturing route of new pharmaceuticals.
• Bioconjugation & Probe Synthesis: The carboxylic acid functionality allows for conjugation to other molecules, useful in creating chemical probes for biological target identification.

Basic Information

Product Name	cis-2-(tert-Butoxycarbonyl)Octahydrocyclopenta[C]Pyrrole-3A-Carboxylic Acid
CAS No.	1445951-33-6
Molecular Formula	C16H25NO4
Molecular Weight	295.37 g/mol
Synonyms	(3aS,7aR)-1-(tert-Butoxycarbonyl)octahydrocyclopenta[c]pyrrole-3a-carboxylic acid; (3aS,7aR)-1-Boc-octahydrocyclopenta[c]pyrrole-3a-carboxylic acid; 1-Boc-3a-carboxyhexahydrocyclopenta[c]pyrrole; cis-1-N-Boc-3a-carboxyhexahydrocyclopenta[c]pyrrole; (3aS,7aR)-1-(tert-Butoxycarbonyl)hexahydro-1H-cyclopenta[c]pyrrole-3a(3H)-carboxylic acid; Bicyclic Proline Derivative; tert-Butyl (3aS,7aR)-3a-carboxyhexahydro-1H-cyclopenta[c]pyrrole-1-carboxylate
EINECS	Contact for details

Quality Control

Our cis-2-(tert-Butoxycarbonyl)Octahydrocyclopenta[C]Pyrrole-3A-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.