Description

8-Bromo-7-Fluoroisoquinoline CAS NO 1445891-57-5 is a high-purity, halogenated isoquinoline derivative serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both bromine and fluorine substituents, makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the halogenated isoquinoline core can contribute to biological activity and environmental stability.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and other advanced electronic materials due to its potential for charge transport and luminescence.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging reagent in the design of chemical probes for studying biological pathways and protein function.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create diverse biaryl and conjugated systems.
• Fluorine Chemistry Exploration: The presence of fluorine allows for the study of fluorine-specific interactions in drug-receptor binding, influencing potency, metabolic stability, and bioavailability.

Basic Information

Product Name	8-Bromo-7-Fluoroisoquinoline
CAS No.	1445891-57-5
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	8-Bromo-7-fluoro-isoquinoline; Isoquinoline, 8-bromo-7-fluoro-; 7-Fluoro-8-bromoisoquinoline; 1445891-57-5; 8-Bromo-7-fluoroisoquinoline; 8-Br-7-F-Isoquinoline
EINECS	Contact for details

Quality Control

Our 8-Bromo-7-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.