Description

8-Bromo-5-Chloro-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate and versatile heterocyclic building block. Its core value lies in its functionalized isoquinoline scaffold, which is critical for synthesizing complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for creating novel drug candidates and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a privileged scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities in drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated structure for bioactivity.
• Fine Chemical Building Block: Employed in organic synthesis to construct more complex heterocyclic compounds for various specialty chemical applications.
• Ligand and Catalyst Development: Potential use in the development of novel ligands for catalytic systems or as a core structure in functional materials.

Basic Information

Product Name	8-Bromo-5-Chloro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1445891-27-9
Molecular Formula	C9H9BrClN
Molecular Weight	246.53 g/mol
Synonyms	8-Bromo-5-chloro-1,2,3,4-tetrahydroisoquinoline; 5-Chloro-8-bromo-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-8-bromo-5-chloroisoquinoline; 8-Bromo-5-chloro-3,4-dihydro-1H-isoquinoline; 1445891-27-9; 8-Br-5-Cl-THIQ
EINECS	Contact for details

Quality Control

Our 8-Bromo-5-Chloro-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high standards, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.