Description

6-Bromo-1-Chloro-5-Fluoroisoquinoline is a high-purity, multi-halogenated isoquinoline derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique halogen substitution pattern, which provides distinct reactivity and electronic properties for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic research.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by leveraging its halogenated heterocyclic core.
• Material Science: Serves as a monomer or functional unit in the creation of specialty polymers, organic semiconductors, and liquid crystals.
• Chemical Biology: Employed as a molecular probe or a tag in bioconjugation chemistry due to its reactive halogen sites.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Library Synthesis: A versatile scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	6-Bromo-1-Chloro-5-Fluoroisoquinoline
CAS No.	1445564-11-3
Molecular Formula	C9H4BrClFN
Molecular Weight	260.49 g/mol
Synonyms	6-Bromo-1-chloro-5-fluoroisoquinoline; 1-Chloro-6-bromo-5-fluoroisoquinoline; 5-Fluoro-6-bromo-1-chloroisoquinoline; Isoquinoline, 6-bromo-1-chloro-5-fluoro-; 1445564-11-3; 6-Br-1-Cl-5-F-isoquinoline
EINECS	Contact for details

Quality Control

Our 6-Bromo-1-Chloro-5-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.