Description

3-Chloro-6-Fluoro-1-Methoxyisoquinoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique halogenated and methoxylated structure makes it a valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides, leveraging its halogenated isoquinoline core.
• Material Science Research: Serves as a precursor for organic light-emitting diodes (OLEDs), liquid crystals, and other electronic materials due to its fused aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring functionalized isoquinoline scaffolds.
• Academic & Industrial R&D: Used extensively in medicinal chemistry and process chemistry research for structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-Chloro-6-Fluoro-1-Methoxyisoquinoline
CAS No.	1443759-45-2
Molecular Formula	C₁₀H₇ClFNO
Molecular Weight	211.62 g/mol
Synonyms	1-Methoxy-3-chloro-6-fluoroisoquinoline; 3-Chloro-6-fluoro-1-methoxy-isoquinoline; 1443759-45-2; 1-Methoxy-3-chloro-6-fluoro-isoquinoline; Isoquinoline, 3-chloro-6-fluoro-1-methoxy-; 3-Chloro-6-fluoro-1-methoxy isoquinoline; 3-Chloro-6-fluoro-1-O-methylisoquinoline
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-6-Fluoro-1-Methoxyisoquinoline is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. Our standard offering meets a typical purity of ≥97% (HPLC), with custom purities available. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with each shipment to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent potential degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.