Description

(R)-tert-Butyl((3-Iodo-2-Methylbut-3-En-1-Yl)Oxy)Diphenylsilane is a high-value, chiral organosilicon building block featuring a reactive vinyl iodide moiety. This compound is essential for advanced organic synthesis, particularly in the construction of complex molecules where stereochemical control is critical. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting specific stereocenters.
• Cross-Coupling Reactions: Serves as a versatile electrophile in palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to form new carbon-carbon bonds.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides with tailored stereochemistry for enhanced activity.
• Material Science Research: Employed in the development of advanced organic materials and liquid crystals where precise molecular architecture is required.
• Asymmetric Synthesis: Utilized in stereoselective transformations to introduce the (R)-configured fragment into target molecules.
• Process Chemistry: Investigated for scalable manufacturing routes of complex organic molecules in pilot plants and kilo labs.

Basic Information

Product Name	(R)-tert-Butyl((3-Iodo-2-Methylbut-3-En-1-Yl)Oxy)Diphenylsilane
CAS No.	1442105-07-8
Molecular Formula	C21H27IOSi
Molecular Weight	450.44 g/mol
Synonyms	(R)-tert-Butyl((3-iodo-2-methylbut-3-en-1-yl)oxy)diphenylsilane; (R)-tert-Butyldiphenyl((3-iodo-2-methylbut-3-en-1-yl)oxy)silane; (3R)-3-Iodo-2-methyl-3-buten-1-yloxy-tert-butyldiphenylsilane; (R)-TBDPS Ether of 3-Iodo-2-methyl-3-buten-1-ol; (R)-1-((tert-Butyldiphenylsilyl)oxy)-3-iodo-2-methyl-3-butene
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl((3-Iodo-2-Methylbut-3-En-1-Yl)Oxy)Diphenylsilane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP guidelines where applicable, and specifications can be tailored to meet specific research or process development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.