Description

tert-Butyl 2-Amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex fused heterocyclic structure. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought after by research institutions, custom synthesis organizations, and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and other specialized therapeutic areas.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores with improved efficacy and selectivity.
• Custom Synthesis & Contract Manufacturing: A vital starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production, where consistent quality is paramount.
• Chemical Biology Probes: Utilized in the development of chemical tools and probes for studying biological pathways and target validation.

Basic Information

Product Name	tert-Butyl 2-Amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate
CAS No.	1440954-94-8
Molecular Formula	C12H19N3O2S
Molecular Weight	269.36 g/mol
Synonyms	6-(tert-Butoxycarbonyl)-4,5,7,8-tetrahydrothiazolo[5,4-d]azepin-2-amine; 2-Amino-6-(tert-butoxycarbonyl)-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine; tert-Butyl 2-amino-6,7-dihydro-4H-thiazolo[5,4-d]azepine-5(4H)-carboxylate; TBTA intermediate; Thiazoloazepine carboxylate derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.