Description

2,2-Dimethyl-1,3-Dioxolane-13C3-4-Methanol CAS NO 1436560-86-9 is a stable isotope-labeled derivative of a key acetal-protected glycerol synthon, where three carbon atoms are enriched with the 13C isotope. This compound is critical for providing an internal standard with identical chemical properties but distinct mass for highly accurate quantitative analysis. It is primarily required by analytical chemists and researchers in pharmaceutical development, metabolomics, and environmental testing who rely on mass spectrometry for precise measurement and traceability.

Application

• Internal Standard for LC/MS and GC/MS: Essential for the accurate quantification of glycerol, glycerides, and related metabolites in complex biological matrices.
• Pharmaceutical Impurity Profiling & PK/PD Studies: Used in the development and validation of methods to track drug metabolites and impurities with high precision.
• Metabolomics & Lipidomics Research: Enables precise tracking and quantification of glycerol-3-phosphate and phospholipid biosynthesis pathways in cellular studies.
• Synthesis of Labeled Complex Lipids: Serves as a protected, isotopically labeled building block for the synthesis of more complex triglycerides or phospholipids for research.
• Food & Beverage Analysis: Applied in the accurate measurement of glycerol content, sweetness, or fermentation byproducts in quality control labs.
• Environmental & Biofuel Research: Used to trace metabolic pathways in microorganisms involved in biofuel production from glycerol.

Basic Information

Product Name	2,2-Dimethyl-1,3-Dioxolane-13C3-4-Methanol
CAS No.	1436560-86-9
Molecular Formula	C613C3H14O3
Molecular Weight	~149.16 g/mol (for 13C3 labeled form)
Synonyms	(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol-13C3; 1,3-Dioxolane-4-methanol, 2,2-dimethyl-, 13C3-labeled; 13C3-Solketal; 13C3-Isopropylidene Glycerol; 13C3-Acetonide Glycerol; Glycerol Acetonide-13C3; (4-Hydroxymethyl-2,2-dimethyl-1,3-dioxolane)-13C3; Isotope Labeled Glycerol Derivative
EINECS	Contact for details

Quality Control

Every batch of our isotope-labeled materials is produced and tested under a strict quality management system. We guarantee high chemical and isotopic purity as verified by NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) detailing batch-specific isotopic enrichment (atom % 13C), chemical purity, and solvent residues are provided to ensure traceability and compliance with your research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use to prevent evaporation and concentration changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C (for three labeled positions)
Isotopic Purity	≥ 99% 13C3
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.