Description

1-(2H-Indazol-3-Yl)-4-{[4-(Methylsulfonyl)Piperazin-1-Yl]Carbonyl}Pyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate designed for research and development in modern drug discovery. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in the synthesis of novel therapeutic agents. It is primarily targeted at pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates targeting specific biological pathways.
• Kinase Inhibitor Research: Used in the development and screening of novel kinase inhibitors due to its indazole and piperazine sulfonyl motifs.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Biochemical Probe Synthesis: Employed in creating specialized molecular probes for investigating enzyme function and cellular signaling mechanisms.
• Contract Research & Development (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for cutting-edge chemical biology and drug discovery projects.

Basic Information

Product Name	1-(2H-Indazol-3-Yl)-4-{[4-(Methylsulfonyl)Piperazin-1-Yl]Carbonyl}Pyrrolidin-2-One
CAS No.	1435986-95-0
Molecular Formula	C17H21N5O4S
Molecular Weight	391.45 g/mol
Synonyms	1-(2H-Indazol-3-yl)-4-[(4-methylsulfonylpiperazin-1-yl)carbonyl]pyrrolidin-2-one; 4-[(4-Methanesulfonylpiperazine-1-carbonyl]-1-(1H-indazol-3-yl)pyrrolidin-2-one; 1-(1H-Indazol-3-yl)-4-{[4-(methylsulfonyl)piperazin-1-yl]carbonyl}pyrrolidin-2-one; CAS 1435986-95-0; 1-(2H-Indazol-3-yl)-4-({4-[(methylsulfonyl)]piperazin-1-yl}carbonyl)pyrrolidin-2-one
EINECS	Contact for details

Quality Control

Our 1-(2H-Indazol-3-Yl)-4-{[4-(Methylsulfonyl)Piperazin-1-Yl]Carbonyl}Pyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.