Description

R-(+)-Pramipexole-D3 Dihydrochloride is a deuterium-labeled, high-purity reference standard of the active pharmaceutical ingredient pramipexole. This compound is critical for ensuring the accuracy and reliability of bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, clinical research organizations, and quality control departments requiring definitive internal standards for mass spectrometry.

Application

• Primary use as an Internal Standard (IS) for the quantitative analysis of pramipexole in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Metabolite identification and drug metabolism and pharmacokinetics (DMPK) studies in pharmaceutical development.
• Method development and validation for bioequivalence and clinical trial sample analysis.
• Quality control and assurance in the manufacturing of pramipexole-based drug products.
• Use in forensic and anti-doping analysis for precise quantification.
• Supporting research into neurological disorders, including Parkinson's disease and restless legs syndrome.

Basic Information

Product Name	R-(+)-Pramipexole-D3 Dihydrochloride
CAS No.	1432230-09-5
Molecular Formula	C10H14D3N3S • 2HCl
Molecular Weight	302.27 g/mol
Synonyms	(6R)-6-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine-D3 dihydrochloride; (R)-Pramipexole-D3 dihydrochloride; SND 919-D3; Mirapex-D3; Pramipexole D3 (labeled); Pramipexole-d3 HCl; 2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole-D3 dihydrochloride
EINECS	Contact for details

Quality Control

Our R-(+)-Pramipexole-D3 Dihydrochloride is manufactured under strict quality systems to ensure the highest standards of chemical and isotopic purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant guidelines for reference standard materials to guarantee reliable and reproducible performance in sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.