Description

Diazoxide-D3 is a deuterium-labeled analog of the antihypertensive and hyperglycemic agent Diazoxide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Diazoxide in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based studies to track drug absorption, distribution, metabolism, and excretion (ADME).
• Bioanalytical Method Development and Validation: Serves as a stable isotope-labeled reference to improve method robustness, accuracy, and precision for regulatory submissions.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Enables accurate measurement of Diazoxide levels in patient samples for dose optimization and safety studies.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of related substances and degradants in active pharmaceutical ingredient (API) batches.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy analytical techniques for definitive method development in reference laboratories.

Basic Information

Product Name	Diazoxide-D3
CAS No.	1432063-51-8
Molecular Formula	C8H4D3ClN2O2S
Molecular Weight	233.68 g/mol (for C8H4D3ClN2O2S)
Synonyms	7-Chloro-3-(methyl-d3)-1,2,4-benzothiadiazine 1,1-dioxide; 7-Chloro-3-(trideuteriomethyl)-2H-1,2,4-benzothiadiazine 1,1-dioxide; Diazoxide (methyl-d3); Diazoxide Internal Standard; Diazoxide-d3; [2H3]-Diazoxide; Diazoxide D3; Diazoxide (D3, methyl)
EINECS	Contact for details

Quality Control

Our Diazoxide-D3 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and residual solvents. We adhere to relevant industry standards for reference materials to support GMP/GLP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.