Description

Pyrazinamide-D3 is a deuterium-labeled analog of the first-line anti-tuberculosis drug Pyrazinamide. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors, particularly those focused on drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and therapeutic drug monitoring for tuberculosis treatment.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the analysis of Pyrazinamide in biological matrices (plasma, serum, urine).
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to track the absorption, distribution, metabolism, and excretion of Pyrazinamide.
• Bioanalytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with FDA and ICH guidelines.
• Therapeutic Drug Monitoring (TDM): Enables precise measurement of drug concentrations in patient samples to optimize tuberculosis treatment regimens and manage toxicity.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of deuterated impurities or related substances in active pharmaceutical ingredient (API) batches.
• Clinical Research: Supports clinical trials for new anti-tuberculosis drugs or combination therapies requiring accurate Pyrazinamide level assessment.

Basic Information

Product Name	Pyrazinamide-D3
CAS No.	1432059-16-9
Molecular Formula	C5H2D3N3O
Molecular Weight	126.13 g/mol
Synonyms	Pyrazinecarboxamide-d3; 2-Pyrazinecarboxamide-d3; PZA-d3; Deuterated Pyrazinamide; [2H3]-Pyrazinamide; Pyrazinamide (phenyl-d3); Nicotinamide-d3 (related but incorrect, included for search clarity); Tuberculosis Drug Internal Standard-d3
EINECS	Contact for details

Quality Control

Our Pyrazinamide-D3 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity (D-enrichment), and impurity profile. We adhere to relevant industry standards for reference materials, and our quality system supports traceability and data integrity for regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.