Description

2-(tert-Butoxycarbonyl)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a reactive bromine substituent. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates, particularly within the fields of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those with tetrahydroisoquinoline scaffolds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its reactive bromine site for further functionalization.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for constructing peptide-like molecules with enhanced metabolic stability.
• Library Synthesis: Employed in combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• API Development: Integral in the research and development stages of new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Used to create specialized molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid
CAS No.	1430563-91-9
Molecular Formula	C15H18BrNO4
Molecular Weight	356.21 g/mol
Synonyms	5-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid, 2-(1,1-dimethylethoxy)carbonyl-; 2-Boc-5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 5-Bromo-2-((tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; Boc-5-Br-Tic-OH; (1S,2R)-2-[(tert-Butoxycarbonyl)amino]-5-bromo-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid (for specific stereoisomer); 5-Bromo-N-Boc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid.
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-5-Bromo-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.