Description

Soticlestat CAS NO 1429505-03-2 is a high-purity, small molecule investigational drug substance. It is a potent and selective inhibitor of cholesterol 24-hydroxylase (CH24H), an enzyme primarily expressed in the brain that plays a key role in cholesterol metabolism. This compound is of significant interest for research and development in the pharmaceutical industry, particularly for targeting neurological conditions. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in neuroscience and CNS drug discovery.

Application

• Pharmaceutical R&D (Active Pharmaceutical Ingredient): Serves as the key active substance in the formulation of investigational new drugs for clinical trials.
• Neuroscience Research: Used as a critical research tool to study the role of the CH24H enzyme and brain cholesterol homeostasis in laboratory settings.
• Preclinical Studies: Essential for conducting in vitro and in vivo studies to evaluate pharmacokinetics, pharmacodynamics, and toxicology profiles.
• Reference Standard: Employed as an analytical standard for method development, validation, and quality control in HPLC, LC-MS, and other analytical techniques.
• Process Chemistry & Scale-up: Used in the development and optimization of synthetic routes for commercial-scale manufacturing.
• Drug Discovery Screening: Acts as a lead compound or positive control in high-throughput screening assays targeting neurological pathways.

Basic Information

Product Name	Soticlestat
CAS No.	1429505-03-2
Molecular Formula	C₂₃H₂₀ClN₃O₃
Molecular Weight	421.88 g/mol
Synonyms	TAK-935; OV935; (1R,2S)-2-[(3-Chloro-4-methoxyphenyl)amino]cyclohexyl 1H-imidazole-4-carboxylate; (1R,2S)-2-[(3-Chloro-4-methoxyphenyl)amino]cyclohexyl 1H-imidazole-4-carboxylate; TAK 935; OV 935; Soticlestat (USAN); UNII-2Q6K3QOC6K
EINECS	Contact for details

Quality Control

Our Soticlestat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical development. Specifications are aligned with ICH guidelines. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.