Description

4-Cyano-1H-Indole-6-Carboxylic Acid is a high-purity, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a carboxylic acid and a nitrile group on the indole scaffold, makes it a versatile intermediate for constructing complex pharmacophores. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and plant growth regulators with novel modes of action.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Bioconjugation & Probe Development: The carboxylic acid group enables coupling to biomolecules (peptides, proteins) for creating fluorescent probes or diagnostic agents.
• Academic & Contract Research: Fundamental reagent for methodological development in organic chemistry and for exploring new chemical spaces in discovery programs.

Basic Information

Product Name	4-Cyano-1H-Indole-6-Carboxylic Acid
CAS No.	1427502-44-0
Molecular Formula	C10H6N2O2
Molecular Weight	186.17 g/mol
Synonyms	6-Carboxy-1H-indole-4-carbonitrile; 1H-Indole-6-carboxylic acid, 4-cyano-; 4-Cyanoindole-6-carboxylic Acid; 4-CN-1H-Indole-6-COOH; 4-Cyano-6-indolecarboxylic Acid; 4-Cyano-1H-indol-6-carbonsäure (German); Acide 4-cyano-1H-indole-6-carboxylique (French)
EINECS	Contact for details

Quality Control

Every batch of 4-Cyano-1H-Indole-6-Carboxylic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with detailed impurity profiling available. A Certificate of Analysis (COA) providing full batch-specific results is supplied with each shipment, supporting compliance in GMP-aligned research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.