Description

2-(Boc-Amino)-5-Chloro-2,3-Dihydro-1H-Indene-2-Carboxylic Acid is a high-purity, protected amino acid derivative featuring a versatile indane scaffold. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of complex molecules with potential therapeutic activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Peptidomimetics & PROTACs: Used to construct non-peptide scaffolds that mimic peptide structure and function, or as a linker component in Proteolysis Targeting Chimeras (PROTACs).
• Medicinal Chemistry Research: Serves as a versatile starting material for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: Employed by fine chemical manufacturers for the contract synthesis of complex, high-value organic molecules for clients.
• Chemical Biology Probes: Utilized in the development of chemical probes to study biological pathways and protein function.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and novel heterocyclic chemistry.

Basic Information

Product Name	2-(Boc-Amino)-5-Chloro-2,3-Dihydro-1H-Indene-2-Carboxylic Acid
CAS No.	1427501-69-6
Molecular Formula	C15H18ClNO4
Molecular Weight	311.76 g/mol
Synonyms	5-Chloro-2-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydro-1H-indene-2-carboxylic acid; 2-[(tert-Butoxycarbonyl)amino]-5-chloro-2,3-dihydro-1H-indene-2-carboxylic Acid; Boc-5-Chloro-D,L-2-aminoindane-2-carboxylic acid; 2-(Boc-amino)-5-chloroindane-2-carboxylic acid; tert-Butyl (5-chloro-2-carboxy-2,3-dihydro-1H-inden-2-yl)carbamate; 2-Amino-5-chloro-2,3-dihydro-1H-indene-2-carboxylic acid, N-Boc-protected; Boc-Amino-5-Chloro-Indane-2-Carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-(Boc-Amino)-5-Chloro-2,3-Dihydro-1H-Indene-2-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.