Description

1H-Isoindol-1-One, 5-Bromo-4-Fluoro-2,3-Dihydro- is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated isoindolone core structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique bromo-fluoro substitution pattern into complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic research.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization due to its halogenated scaffold.
• Agrochemical Synthesis: Intermediate in the development of novel pesticides and herbicides, leveraging its bioactive heterocyclic structure.
• Fine Chemical Production: Serves as a precursor for specialized dyes, pigments, and functional materials requiring specific halogenated motifs.
• Academic Research: Utilized in university and institutional labs for exploring new organic reactions and heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process scale-up services.

Basic Information

Product Name	1H-Isoindol-1-One, 5-Bromo-4-Fluoro-2,3-Dihydro-
CAS No.	1427426-23-0
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	5-Bromo-4-fluoro-2,3-dihydro-1H-isoindol-1-one; 5-Bromo-4-fluoro-2,3-dihydroisoindol-1-one; 5-Bromo-4-fluoro-1-oxo-2,3-dihydro-1H-isoindole; 2,3-Dihydro-5-bromo-4-fluoro-1H-isoindol-1-one; 1427426-23-0; 5-Bromo-4-fluoro-1-isoindolinone; 5-Bromo-4-fluoro-isoindolin-1-one
EINECS	Contact for details

Quality Control

Our 1H-Isoindol-1-One, 5-Bromo-4-Fluoro-2,3-Dihydro- is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.