Description

6-Chloro-4-Oxo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1427195-17-2. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex heterocyclic scaffolds essential for drug discovery. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates, especially kinase inhibitors.
• Organic Synthesis Building Block: Serves as a versatile synthon for constructing complex isoquinoline and fused heterocyclic systems in academic and industrial R&D.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects and scale-up activities.
• Process Chemistry Development: Employed in route scouting and process optimization for the efficient, scalable production of target molecules.

Basic Information

Product Name	6-Chloro-4-Oxo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1427195-17-2
Molecular Formula	C₁₄H₁₄ClNO₃
Molecular Weight	279.72 g/mol
Synonyms	tert-Butyl 6-chloro-4-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylate; 1H-Isoquinoline-2-carboxylic acid, 6-chloro-3,4-dihydro-4-oxo-, 1,1-dimethylethyl ester; 6-Chloro-4-oxo-1,4-dihydroisoquinoline-2-carboxylic acid tert-butyl ester; 6-Chloro-4-oxo-3,4-dihydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-chloro-4-oxo-1,4-dihydroisoquinoline-2-carboxylate; CAS 1427195-17-2
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Oxo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.