Description

6-Chloro-4-Hydroxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key synthetic building block, enabling the construction of complex molecular architectures with high stereochemical control. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly within the fields of central nervous system (CNS) and cardiovascular drug research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Heterocyclic Compound Synthesis: Serves as a key reactant for constructing complex isoquinoline and tetrahydroisoquinoline-based compounds.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the efficient production of target molecules under GMP-like conditions.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	6-Chloro-4-Hydroxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1427195-07-0
Molecular Formula	C₁₄H₁₆ClNO₃
Molecular Weight	281.74 g/mol
Synonyms	tert-Butyl 6-chloro-4-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate; 6-Chloro-4-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylic acid 1,1-dimethylethyl ester; 6-Chloro-4-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 6-Chloro-4-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 1,1-dimethylethyl ester; 6-Chloro-4-hydroxy-1,2,3,4-tetrahydro-isoquinoline-2-carboxylic acid tert-butyl ester; 6-Chloro-4-hydroxy-3,4-dihydroisoquinoline-2-carboxylic acid tert-butyl ester; 6-Chloro-4-hydroxy-3,4-dihydro-2H-isoquinoline-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Hydroxy-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.