Description

D-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3 is a high-purity, isotopically labeled derivative of the amino acid L-DOPA, specifically designed for advanced analytical and research applications. This compound matters as a critical internal standard and tracer in quantitative mass spectrometry, enabling precise measurement and metabolic pathway elucidation. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require the highest levels of accuracy and reliability in their analytical methods.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of L-DOPA and related metabolites in complex biological matrices like plasma, serum, and cerebrospinal fluid.
• Metabolic Pathway Tracing: Employed in pharmacokinetic and pharmacodynamic studies to track the absorption, distribution, metabolism, and excretion (ADME) of dopaminergic drugs.
• Biomarker Research: Facilitates the discovery and validation of biomarkers associated with neurological disorders such as Parkinson's disease.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredient (API) manufacturing.
• Stable Isotope Labeling in Proteomics: Serves as a building block for the synthesis of isotopically labeled peptides and proteins for quantitative proteomics studies.
• Reference Material for NMR Spectroscopy: Acts as a deuterated reference compound to aid in structural elucidation and method development.

Basic Information

Product Name	D-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3
CAS No.	1426174-46-0
Molecular Formula	C9H5D7NO3
Molecular Weight	197.25 g/mol (calculated)
Synonyms	D-[2,3,3-2H3; Ring-2H4]DOPA; (R)-2-Amino-3-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)-2,3,3-trideuteriopropanoic Acid; Deuterated D-DOPA; D-DOPA-d7; Isotopically Labeled D-DOPA; D-3,4-Dihydroxyphenylalanine-d7 (isomeric form); D-4-Hydroxyphenyl-d4-alanine-2,3,3-d3
EINECS	Contact for details

Quality Control

Our D-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive analytical applications. Each lot undergoes rigorous testing, including isotopic purity assessment by NMR and mass spectrometry, and chemical purity determination by HPLC. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.