Description

(S)-(-)-Carbidopa-D5 is a deuterated isotopologue of the pharmaceutical compound Carbidopa, specifically labeled with five deuterium atoms. This high-purity reference standard is critical for ensuring analytical accuracy and reliability in quantitative bioanalysis and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies for applications requiring precise internal standardization.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the accurate quantification of Carbidopa in complex biological matrices (e.g., plasma, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical research.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the metabolic pathways of Carbidopa.
• Quality Control in Manufacturing: Supports in-process testing and final product release testing for Carbidopa-containing pharmaceutical formulations.
• Forensic and Doping Control Analysis: Provides a reliable reference for confirmatory testing in forensic toxicology and anti-doping programs.

Basic Information

Product Name	(S)-(-)-Carbidopa-D5
CAS No.	1426174-03-9
Molecular Formula	C10H9D5N2O4
Molecular Weight	229.26 g/mol
Synonyms	(S)-3-(3,4-Dihydroxybenzyl)-2-hydrazino-2-methyl-3,3,4,4,5-pentadeuteropropanoic Acid; Carbidopa-d5; L-Carbidopa-D5; (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methyl-3,3,4,4,5-pentadeuteropropanoic Acid; MK-486-D5; Lodosyn-D5
EINECS	Contact for details

Quality Control

Our (S)-(-)-Carbidopa-D5 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, chemical purity, isotopic enrichment, and specific tests for residual solvents and impurities. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.