Description

Cefaclor-D5 CAS NO 1426173-90-1 is a deuterated isotopologue of the second-generation cephalosporin antibiotic, Cefaclor, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research and development, clinical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, bioanalytical method development, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application in the quantitative bioanalysis of Cefaclor in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioequivalence Studies: Enables precise measurement of drug concentration over time to assess absorption, distribution, metabolism, and excretion (ADME).
• Drug Metabolism Research: Used to track and quantify metabolites, facilitating a deeper understanding of a drug's metabolic pathways.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports the development and validation of assays for monitoring antibiotic levels in patients to optimize dosing regimens.
• Quality Control in Pharmaceutical Manufacturing: Serves as a reference standard for ensuring the purity and potency of Cefaclor in active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Anti-Doping Analysis: Provides a reliable isotopic standard for confirmatory testing in specialized analytical laboratories.

Basic Information

Product Name	Cefaclor-D5
CAS No.	1426173-90-1
Molecular Formula	C15H9D5ClN3O4S
Molecular Weight	Contact for details
Synonyms	(6R,7R)-7-[[(2R)-2-Amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid-d5; 3-Chloro-7-D-phenylglycylamido-3-cephem-4-carboxylic Acid-d5; Cefaclor (phenyl-d5); Cefaclor-d5 (Major); Cefaclor (phenyl ring-d5); Stable Isotope Labeled Cefaclor; Cefaclor Internal Standard
EINECS	Contact for details

Quality Control

Our Cefaclor-D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and identification (by NMR and MS). We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance as an internal standard. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.